The mission of the Centre for Systems Medicine is to provide a translational research centre which identifies genes, proteins and metabolites implicated in human disease. The Centre utilizes bioinformatics, systems biology and machine learning approaches to develop new prognostic tools for the treatment of cancer, neurological and metabolic disorders and to develop more targeted therapies for patients.
What is Systems Medicine?
For a short and understandable explanation please watch the animation provided by ZonMw
CSM Director, Prof. Jochen Prehn provides and overview of the research activities at the Centre for Systems Medicine
For additional Videos, click on each investigator’s page to learn about what projects they are leading at the CSM
CSM Director: Prof. Jochen Prehn
CSM Scientific Liaison Officer: Dr. Helena Bonner
Recent Highlights:
Steroid-free combination of 5-azacytidine and venetoclax for the treatment of multiple myeloma (2024)
BOK CONTROLS ER PROTEOSTASIS AND PHYSIOLOGICAL ER STRESS RESPONSES IN NEURONS
Patients with mesenchymal tumours and high Fusobacteriales prevalence have worse prognosis in colorectal cancer (CRC)
Angiogenin and tRNA fragments in Parkinson’s disease and neurodegeneration.
System-based approaches as prognostic tools for glioblastoma
Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform
Click here for a list of all the Publications