Familial Colorectal Cancer Genetic Study Published
Lynch Syndrome (LS) is an inherited predisposition to a range of cancers, notably uterine cancer in females and colorectal cancer (CRC) in both sexes, caused by a deficiency in mismatch …
Activation of apoptosis executor BAX is mediated by intra-molecule charge transfer
Results of a collaboration between the Centre for Systems Medicine (CSM) and the Central European Institute of Technology (CEITEC), Masaryk University, Brno have been recently published in the highly respected theoretical …
Seminar: Clinical & Molecular Oncology
Seminar by invited speaker: Professor Dr Peter Daniel Charité Campus Virchow-Klinikum, Humboldt University & Max-Delbrück-Center for Molecular Medicine, Berlin, Germany Unexpected findings in the regulation of the Bak pathway in …
Major international study to improve treatment for colorectal cancer patients
The Centre for Systems Medicine at the Royal College of Surgeons in Ireland (RCSI) is leading an international team of scientists on a major research study which aims to predict …
Reviews on multi-protein interplay and drug synergies during apoptotic cell death published
The Centre of Systems Medicine has published two review articles which describe key molecular processes and signalling network topologies coordinating apoptosis signal transduction. Christian T Hellwig and Markus Rehm published …
Systems Modelling identifies key switches between cell death and survival during neuronal energy crisis
A study by David Davila, Niamh M. C. Connolly, Helena Bonner, Petronela Weisová, Heiko Dussmann, Caoimhín G. Concannon, Heinrich J. Huber and Jochen H. M. Prehn was accepted to the …
Double Strike for Theoretical Systems Biology @CSM !
The year 2012 started well for the Centre of Systems Medicine by providing two new studies that extend the Centre of Systems Medicine’s competency in methodological approaches and address, for …
Launch of the Centre for Systems Medicine- January 11th 2012!!
On behalf of RCSI and Prof. Jochen Prehn, you are cordially invited to the launch of the Centre for Systems Medicine Albert Lecture Theatre, Royal College of Surgeons in Ireland, …
New England Journal of Medicine Publication!
TFAP2E gene hypermethylation associated with clinical non-responsiveness to chemotherapy in colorectal cancer In many cancers different patterns of DNA methylation (epigenetics) appear likely to discriminate aggressive versus nonaggressive disease and …
Successful Publication in GUT!
This month the centre successfully published results on the Clinical Application of a systems model of apoptosis execution for the preditiction of colorectal cancer therapy responses and personalisation of therapy. …